GLP-1: Molecular mechanisms and outcomes of a complex …
WEBThis review will encompass the synthesis, secretion, and metabolism of GLP-1, the structure and expression of the GLP-1r, the intracellular signaling initiated by GLP-1r stimulation, and GLP-1 changes after bariatric surgery.
Glucagon-like peptide 1-based therapies for the treatment of ... - UpToDate
WEBAug 26, 2024 · Learn how GLP-1 receptor agonists, dual-acting GLP-1 and GIP receptor agonists, and DPP-4 inhibitors affect glucose control and weight loss in patients with type 2 diabetes. Compare their mechanisms, efficacy, safety, and administration.
Metabolic Messengers: glucagon-like peptide 1 - Nature
WEBJan 11, 2021 · Glucagon like peptide-1 (GLP-1), a peptide hormone from the intestinal tract, plays a central role in the coordination of postprandial glucose homeostasis through actions on insulin secretion,...
Glucagon-like peptide 1 (GLP-1) - PMC - National Center for ...
WEBSep 30, 2019 · Depending on the molecule (native GLP-1 or a longer-acting GLP-1 analog) and the route of administration, GLP-1 and its analogs seem to engage different signaling pathways to either directly or indirectly transmit the …
Glucagon-like peptide-1 receptor: mechanisms and advances in …
WEB4 days ago · GLP-1 signaling pathway. GLP-1 initiates signaling by binding to its receptor, GLP-1R, which is a G-protein-coupled receptor. 176,177 When GLP-1 binds to GLP-1R, it triggers the...
Activation of the GLP-1 Receptor Signalling Pathway: A Relevant ...
WEBMay 22, 2011 · GLP-1 is one of the most potent substances known to stimulate glucose-induced insulin secretion (GIIS), and its stimulatory activity is exerted via binding to its receptor on beta cells. This binding results in activation of adenylyl cyclase with consequent production of cAMP and subsequent activation of PKA and the Epac family.
Mechanisms of Action and Therapeutic Application of Glucagon-like Peptide-1
WEBGLP-1 acts through the GLP-1 receptor (GLP-1R) expressed on islet β cells and δ cells to control insulin and somatostatin (SMS) secretion, respectively. SMS in turn inhibits glucagon secretion from islet α cells via the somatostatin-2 receptor (SSTR2).
The GLP-1 journey: from discovery science to therapeutic impact
WEBJan 16, 2024 · This article reviews the discovery and development of GLP-1, a peptide hormone that regulates glucose homeostasis and food intake. It also compares and contrasts GLP-1 with GIP, another incretin peptide, and discusses the mechanisms and implications of GLP-1 receptor signaling.
GLP-1 receptor signalling promotes β-cell glucose metabolism
WEBJun 1, 2017 · Glucagon-like peptide-1 (GLP-1) promotes insulin secretion from pancreatic β-cells in a glucose dependent manner. Several pathways mediate this action by rapid, kinase...
GLP-1: Molecular mechanisms and outcomes of a complex ... - PubMed
WEBOne such hormone, glucagon-like peptide-1 (GLP-1), has received significant attention in the treatment of obesity and diabetes due to its potent incretin effect. In addition to the peripheral actions of GLP-1, this hormone is able to alter behavior through the modulation of multiple neural circuits.