Bradfordsville is a home rule-class city in Marion County, Kentucky, in the United States. The population was 270 at the time of the 2020 census. The community at the site was first known as Centerville from its supposed location at the center of the state. The settlement was renamed Bradford's Mill after Peter Bradford's combined saw- and gristmill at the site; this became "Bradfordsville" after the establishment of a post office in 1834.