Cusseta is a town in Chambers County, Alabama, United States. Situated between Opelika and Lanett, it was named for the ancient Creek Indi…Cusseta is a town in Chambers County, Alabama, United States. Situated between Opelika and Lanett, it was named for the ancient Creek Indian town of Cusseta. As of the 2010 census, its population was 123.