Learn which TV channel or how to live stream the NFL Week 2 New Orleans Saints and San Francisco 49ers game, Sunday, Sept. 14.

Kickoff from Caesars Superdome is set for 1 p.m. ET. San Francisco is a 3-point favorite in the latest 49ers vs. Saints odds from SportsLine consensus, while the over/under for total points scored is set at 40.5. Before making any Saints vs. 49ers picks, make sure you check out the NFL picks from the SportsLine Projection Model.

The 49ers enter Sunday’s game in New Orleans seeking to open a season with back-to-back road wins like in 2019, ’21 and ’23.

The San Francisco 49ers will be without their quarterback in Week 2 vs. the New Orleans Saints, but signs on their star RB are good.

The 49ers are expected to be without starting quarterback Brock Purdy and tight end George Kittle, but they still have some weapons remaining on offense, and their defense is no picnic to deal with either.

After seeing teams in action in Week 1 as well as some notable injuries, we've seen some major NFL line movement for Week 2 games

Who's under pressure, and who is an X-factor? Why these players could be the difference in the New Orleans Saints' outcome against the 49ers:

Find out how to watch San Francisco 49ers vs. New Orleans Saints live streaming online, plus TV channel and game info for this week 2 NFL matchup.

The New Orleans Saints' defense doesn't seem to be underestimating San Francisco 49ers backup quarterback Mac Jones in Week 2.