The Jacksonville Jaguars (4-12) are 4.5-point underdogs in a road AFC South matchup against the Indianapolis Colts (7-9) on Sunday, January 5, 2025 at Lucas Oil Stadium.NFL odds courtesy of BetMGM

Strangely, vibes are much better on the sidelines of the 4-12 team than the one at 7-9. While a loss is better for the Jaguars' chances at getting a top-five pick — even the first pick is still an outside shot — they are not playing with that mentality. Even if the Colts sneak out a victory here, it will not be by more than five points.

As it stands, Jacksonville holds 10 picks in the 2025 NFL Draft. They’re slated to pick once in the first round, once in the second round, twice in the third and fourth round, once in the fifth round, twice in the sixth round and once in the seventh round.

Colts ruled out QB Anthony Richardson for Sunday's regular-season finale vs. the Jaguars due to his back injury. One final start this season for Colts QB Joe Flacco. Richardson missed Week 17 because of his back issues while Flacco took over to throw for 330 yards, two scores and two turnovers in a 45-33 shootout loss to the New York Giants.

Jacksonville’s third win of the 2022 season, 26-11 in the season finale, knocked the Colts out of the playoffs

NFL Week 18 odds, picks, predictions, TV channel, streaming information for Sunday football game between Jacksonville Jaguars and Indianapolis Colts.

Preview the Week 18 matchup between the Indianapolis Colts and Jacksonville Jaguars with predictions, odds, over/under, spread, betting lines and more.