The Florida Gators battle the LSU Tigers in an SEC matchup during Week 3 of the college football season on Saturday

LSU is a 6.5 point favorite against Florida, according to the latest updated game lines posted to FanDuel Sportsbook. FanDuel lists the total at 47.5 points for the matchup. And it set the moneyline odds for LSU at -250 and for Florida at +202 to win outright.

The Florida Gators, led by quarterback DJ Lagway, face the No. 3 LSU Tigers, led by quarterback Garrett Nussmeier, on Saturday, Sept. 13, 2025 at Tiger Stadium in Baton Rouge, La.

Lainey Wilson and the SEC Nation crew made their picks for the marquee matchups between LSU and Florida on Saturday night.

Florida football coach Billy Napier offered some further detail following DL Brendan Bett's spitting incident against USF last week.

LSU tight end Trey'Dez Green is doubtful. Green left the Louisiana Tech contest with a knee injury and was seen wearing a knee brace on the sideline. Green is a critical piece of LSU's red zone attack, and the Tigers' offense will have to figure out a new plan of attack without the five-star tight end.

A win over Florida helped LSU get a woebegone season back on track last season, as the Gators used their 27-16 victory to spark a four-game winning streak to end the 2024 campaign. Florida will be hoping for another season-shifting result on Saturday night as it travels to face the No. 3 Tigers.

The status for one of Florida's defensive linemen was determined the day before the Gators' head to LSU for a Saturday night showdown.