Kickoff from Caesars Superdome is set for 1 p.m. ET. San Francisco is a 3-point favorite in the latest 49ers vs. Saints odds from SportsLine consensus, while the over/under for total points scored is set at 40.5. Before making any Saints vs. 49ers picks, make sure you check out the NFL picks from the SportsLine Projection Model.

The San Francisco 49ers already ruled Brock Purdy out for Week 2, forcing them to turn to Mac Jones at quarterback. With rookie Kurtis Rourke still recovering from a torn ACL, the team elevated former UFL MVP Adrian Martinez to its active roster.

The San Francisco 49ers downed the Seattle Seahawks in Week 1. How did it affect how Kyle Shanahan's team is being viewed in Week 2.

The first thing Staley did as Saints DC was trade for 330-pound nose guard Davon Godchaux, an absolute beast who is a nightmare to handle at the 0 technique. Thoughts and prayers to Niners center Jake Brendel this week.

Kyle Shanahan's team could be without quarterback Brock Purdy for nearly a month after the 49ers won their opening NFL game.

San Francisco tabbed Trey Lance over Jones in 2021 after a trade, with neither first-rounder panning out. Now, Jones will start in Brock Purdy's absence

The San Francisco 49ers announced the team signed veteran kicker Eddy Piñeiro Jr. to a one-year deal on Wednesday, a day after placing Jake Moody on waivers​.

Jake Tonges is a 26-year old tight end for the San Francisco 49ers. He measures up at 6-foot-4 and 240 pounds. He came to the NFL in 2022 as an undrafted free agent signee with the Chicago Bears. Jake Tonges was originally born in Cincinnati, but he attended Los Gatos High School in California, which is about an hour from San Francisco.