See who's in and who's out for the Week 3 matchup between the San Francisco 49ers and Los Angeles Rams on September 22, 2024.

Although the famed Rams-49ers rivalry has been decidedly tilted in San Francisco’s direction in recent years, the games have still been must-see spectacles.

Just two games into the season, the Rams (0-2) are approaching desperate times as they prepare to face the San Francisco 49ers (1-1) Sunday afternoon at SoFi Stadium. The list of issues thus far for the Rams is probably as long as their injury report.

The Rams have their work cut out for them in Week 3 but they have a chance to upset the 49ers if they win these 5 matchups

If Kittle does miss Sunday's game, he will join star running back Christian McCaffrey, who is currently on the Injured Reserve list with a calf injury and Achilles tendonitis. Wide receiver Deebo Samuel is also missing time following a calf injury he suffered in Week 2. Quarterback Brock Purdy is running low on targets to throw to.

The Los Angeles Rams host the San Francisco 49ers on Sunday as both NFC West rivals try to shake off dismal Week 2 performances.