Allostery can be defined as the regulation of protein function, structure and/or flexibility induced by the binding of a ligand or another protein, termed an effector, at a site away from the active ...

Figure 1: FPP synthesis and mevalonate pathway. In the present work, we determine a crystal structure of FPPS in complex with FPP. Intriguingly, the product is bound not to the active site, but to the ...

Enzymes work extremely reliably, however they are highly selective. They transform molecules that arise in nature into the precise form required by a cell or organism. However, they often only convert ...