Angiotensin II (AT-II)-Receptor Antagonists are Reviewed. Research focused on blocking the renin- angiotensin system (RAS) led to the discovery of angiotensin-converting-enzyme (ACE) inhibitors ...

The potential benefit of angiotensin II-receptor antagonism is not limited to well-tolerated blood pressure control. Angiotensin II has complex effects on the heart and kidneys. Blocking the ...

An orally active, selective antagonist of the angiotensin II type 1 (AT1) receptor and the endothelin-A receptor, sparsentan has anti-inflammatory, anti-proliferative, and anti-fibrotic effects.

The dual-action agent LCZ696 blocks the angiotensin II receptor (via a valsartan moiety) and inhibits neprilysin (via an AHU377 moiety). In a phase II trial, this drug “demonstrated superior ...

—David Charytan, MD, MSc, Chief of the Nephrology Division at New York University Grossman School of Medicine, discusses the use of ACE inhibitors, angiotensin receptor blockers, and newer ...