TLR and RIG-I – two antiviral innate immunity pathways: Some viruses enter cells through the endocytic machinery. The genomes of such viruses are detected by members of TLR family of receptor ...

In particular, type III interferons appeared to play a crucial role in the mucosal antiviral immunity of Egyptian fruit bats: After infection with a variety of zoonotic viruses, bat organoids ...

New antiviral response discovered in mammals Date: October 10, 2013 Source: ETH Zurich Summary: Researchers have discovered a part of the innate immune system in mice that had only been known in ...

More information: Zixuan Wang et al, Direct lysine dimethylation of IRF3 by the methyltransferase SMYD3 attenuates antiviral innate immunity, Proceedings of the National Academy of Sciences (2025 ...

Innate immunity is activated when the pattern recognition receptors (PRRs) recognize pathogen-associated molecular patterns (PAMPs). We show that a liver-derived secretory protein LECT2, a ...

An interesting new study describes the activities of a family of viral enzymes called two-histidine-phosphoesterases (2H-PEs), found in coronaviruses (CoVs) and rotaviruses, as well as a mammalian ...

Innate antiviral immunity includes secretion of type I interferons, antiviral cytokines, and certain cellular responses, including neutrophils, monocytes and macrophages, ...

A new study identified an antiviral drug that activates the innate immune system and appears to have strong prophylactic and therapeutic potential in mice. It could both prevent and treat Covid-19 ...

Trained immunity is a form of innate immune cell memory that is being developed as a novel immunotherapeutic approach for cancer treatment.

This enhanced innate immunity likely enables bats to control viral replication early, contributing to their resistance to severe disease from highly pathogenic viruses.