In DNA and RNA, purines pair with their complementary pyrimidine bases ... GTP is also a substrate for the synthesis of RNA during transcription. Purine metabolism involves the synthesis and breakdown ...

These nucleotides can then be further processed to form the pyrimidine bases found in DNA and RNA. The pyrimidine biosynthetic pathway is tightly regulated to ensure the proper balance of nucleotides ...

Single-cell RNA sequencing (scRNA-seq) has confirmed that MM exhibits high intra-tumor heterogeneity, comprising a mixture of ...

The central dogma of molecular biology suggests that the primary role of RNA is to convert the information stored in DNA into proteins. In reality, there is much more to the RNA story. However ...

Stanford Medicine researchers have developed a blood test capable of detecting cancers, the ways cancer resists treatments ...

RNA is often compared to a copy from a reference book, or a template, because it carries the same information as its DNA template but is not used for long-term storage. Each ribonucleotide base ...

These insights from researchers could have major implications for diseases like cancer, where gene expression goes awry.

The findings overturn the long-held idea that most types of RNA viruses are incapable of DNA integration and raise another safety concern in the use of RNA-based gene therapy. "It's a very interesting ...

The TDP-43 RNA-binding protein is found in abnormal cytoplasmic inclusions in affected motor neurons in almost all ALS cases, and mutations in the TDP-43 gene (TARDBP) cause a rare form of familial ...

She studies circular RNAs formed as a result of so-called molecular mistakes that occur when a strand of RNA—the ribonucleic ...