Notably, bisphosphonates bind to hydroxyapatite in bone, where they are incorporated into the mineral matrix. Release of the drug from the bone mineral matrix requires bone resorption, and ...

Alendronate (Fosamax, Fosamax Plus D, and generic), the first bisphosphonate approved by the Food and Drug Administration for the treatment and prevention of osteoporosis, came on the market in ...

Alendronate, a nitrogen-containing bisphosphonate ... Should severe ulcerations of the nasal mucosa develop, the drug must be immediately discontinued. Intranasal calcitonin has the ability ...

Estrogen, Evista, Fosteum, the bisphosphonates, and miacalcin all work in this ... can catch up and increase the bone density or bone strength. In other words, these medication change your bone ...

Nitrogen-containing bisphosphonates can induce apoptosis if sufficient levels of the drug are internalized by cells. At micromolar concentrations, apoptosis in other cell types can also be induced ...

It was the first drug in its class—called bisphosphonates—with this oral dosage. You have to take a daily or weekly bisphosphonate on an empty stomach and stay upright for 30 minutes ...

Bisphosphonates (BPs ... in cancer patients Treatment with an amino-BP over long time periods causes the drug to accumulate in an inactive state within the alveolar bone Physical trauma or ...