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Nature17y
Tumor targeting carboxylesterase fused with anti-CEA scFv improve the anticancer effect with a less toxic dose of irinotecan | Cancer Gene Therapy - Nature
Carboxylesterase activity assay. The culture medium of HeLa cells transfected with pF39-sCE2 or pSectag2 were concentrated 10 times using Protein-Concentrate kit (Millipore, Billerica, MA).
ascopubs.org20y
The in vitro metabolism of irinotecan (CPT-11) by carboxylesterase and β-glucuronidase in human colorectal tumours | Journal of Clinical Oncology - ASCO Publications
The purpose of this study was to examine the role of carboxylesterase and β-glucuronidase in the in vitro production of SN-38. Methods: The production of SN-38 from CPT-11 and SN-38G (19.2, 9.6 and ...
ascopubs.org6y
Randomized phase II trial of the carboxylesterase (CES)-converted novel drug EDO-S7.1 in patients (pts) with advanced biliary tract cancers (BTC). - ASCO Publications
Randomized phase II trial of the carboxylesterase (CES)-converted novel drug EDO-S7.1 in patients (pts) with advanced biliary tract cancers (BTC). Ulrich-Frank Pape , Stefan Kasper , Johannes Meiler , ...