Rec8 joins the whole length of the sister chromatids together, and, as meiosis proceeds, is lost in a stepwise manner that correlates with the loss of sister-chromatid cohesion. Figure 1 ...

The centromere, a specialized region of the chromosome, serves as a recruitment platform for diverse proteins crucial for maintaining sister chromatid cohesion and for the assembly of kinetochores.

Since sister chromatids are identical to each other, recombination with a sister chromatid is expected, in most cases, to be a precise way for repairing DNA damage. Recombination between 2 different ...