The fms-like tyrosine kinase 3 (FLT3) plays an important role in both normal and malignant hematopoiesis. Activating mutations in the FLT3 receptor can be detected in approximately 30% of acute ...

The molecular basis of phospho-tyrosyl-regulation of Src-family and Syk-family protein tyrosine kinases in signaling pathways is a current focus of the lab. The conformational activation of Src kinase ...

RET, a transmembrane receptor tyrosine kinase, plays a crucial role in various ... and the aggressive nature of RET mutations in the cytoplasmic region, which are linked to MEN2B.

More information: A 3-week pause versus continued Bruton tyrosine kinase inhibitor use during COVID-19 vaccination in individuals with chronic lymphocytic leukaemia (IMPROVE trial): a randomised, open ...

VEGF-blocking antibodies or tyrosine kinase inhibitors are routinely used ... Conditional strategies to delete the EphB4 cytoplasmic domain and to remove EphB receptors in various cell types ...