They also found that after the extra chromosome was removed, genes tied to nervous system development were more active and ...

Japanese researchers have successfully eliminated the extra chromosome responsible for Down syndrome using CRISPR gene ...

Though Down syndrome comes from the genes themselves, this is generally due to errors between a sperm and an egg, when the genetic information that forms a child first combines and copies.

Down syndrome, the most common genetic cause of intellectual disabilities, was first described in 1866, during an era of great change in our understanding of genetics and evolution. Because of its ...

Using genetic mapping, the researchers identified a gene on human chromosome 21 called Dyrk1a, which causes heart defects when present in three copies in the mouse model of Down syndrome. This ...

Down syndrome is a genetic disorder that occurs when a person receives an extra copy of their chromosome 21, known as Trisomy 21. The additional genetic material disrupts typical development ...

DSCAM gene triplication causes excessive GABAergic synapses in the neocortex in Down syndrome mouse models. PLOS Biology , 2023; 21 (4): e3002078 DOI: 10.1371/journal.pbio.3002078 Cite This Page : ...

Down syndrome: Genetic disorder, usually with physical traits. People with this condition are often social and friendly. Their language development is similar to that of more typical children.

The gene in question, called Down syndrome cell adhesion molecule, or DSCAM, is also implicated in other human neurological conditions, including autism spectrum disorders, ...

Scientists have diagnosed Down syndrome from DNA in the ancient bones of seven infants, one as old as 5,500 years. Their method, published in the journal Nature Communications, may help ...

Back in 1900 the life expectancy of people with Down Syndrome was 9 years. In 1984, it was 28 years, today it's leveled off ...

Leveraging genetic mapping, scientists pinpointed a gene on human chromosome 21 named Dyrk1a. In the mouse model of Down syndrome, having three copies of this gene leads to heart defects.While ...