The endoderm layer destined to be primitive gut is a mosaic of earlier visceral endoderm and definitive endoderm that arises later, during gastrulation. Live imaging now reveals that in mouse embryos, ...

Foxa transcription factors help endow the competence to activate liver genes in development by binding to regulatory sequences in precursor endoderm and opening a local domain of chromatin. Fibroblast ...

Pluripotent stem cells, created from human skin or mouse ear tissue, are shown here becoming endoderm cells. The endoderm is one of the three primary germ layers that ultimately contribute to the ...

Making endoderm cells is the first step toward making insulin-secreting beta cells for diabetes cell replacement therapy. Shown here are beta cells (red) generated from human embryonic stem cells.

An unexpectedly versatile and regenerative stem cell in early embryos may be key to creating new effective fertility treatments, suggests a new study in mice from the University of Copenhagen. It ...

Before a pancreas is a pancreas, it's part of the endoderm, one of three layers of cells in a developing embryo that eventually form its organs. Researchers have now uncovered key genetic signals ...

How do cells turn into organs? During embryonic development, three germ layers form, known as the endoderm, the mesoderm, and the ectoderm. These germ layers give rise to different parts of the ...