Randomized controlled trials could be harming nonprofits, experts argue

In the 1940s, medical researchers began using randomized controlled trials to assess the efficacy of health interventions. In ...
Medscape

Design Differences Likely Explain Mixed Results in Conduction System Pacing vs Biventricular Pacing Trials

Discordant results from two trials comparing conduction system pacing with biventricular pacing for cardiac resynchronization therapy (CRT) leave open the question of whether conduction system pacing ...
ascopubs.org

Using the Expected Survival to Explain Differences Between the Results of Randomized Trials: A Case in Advanced Ovarian Cancer

Use of Genetic Testing and Prophylactic Mastectomy and Oophorectomy in Women With Breast or Ovarian Cancer From Families With a BRCA1 or BRCA2 Mutation Materials and Methods: A proportional hazards ...
The New England Journal of Medicine

Community-Based Cluster-Randomized Trial to Reduce Opioid Overdose Deaths

Evidence-based practices for reducing opioid-related overdose deaths include overdose education and naloxone distribution, the use of medications for the treatment of opioid use disorder, and ...
The New England Journal of Medicine

Randomized Trial of Targeted Indoor Spraying to Prevent Aedes-Borne Diseases

Targeted indoor residual spraying focuses insecticide applications on common resting surfaces of Aedes aegypti mosquitoes (an arboviral disease vector) in houses, such as exposed lower sections of ...
ascopubs.org

Randomized trial of standard chemotherapy alone or combined with atezolizumab as adjuvant therapy for patients with stage III deficient DNA mismatch repair (dMMR) colon cancer ...

NIVOPOSTOP (GORTEC 2018-01): A phase III randomized trial of adjuvant nivolumab added to radio-chemotherapy in patients with resected head and neck squamous cell carcinoma at high risk of relapse.