Excedrin Migraine and Excedrin Extra Strength. Both brands contain the same active ingredients: acetaminophen, aspirin, and caffeine. However, they are marketed to serve different purposes.

Each caplet contains 250 mg acetaminophen, 250 mg aspirin, and 65 mg caffeine. Excedrin Extra Strength is another FDA-approved OTC medication designed to treat a variety of minor aches and pains ...