SANTA CLARA—The West Coast heatwave wreaked havoc on the 49ers’ practice schedule this past week, leading coach Kyle Shanahan to joke that he, like his players, will take intravenous fluids to rehydrate. “I still do it, if I had too much fun the night before,” Shanahan said.

The 49ers just blew another 10-point fourth quarter lead and lost 24-23 to the Arizona Cardinals. Now the 49ers are 2-3. Here are their grades for this pathetic performance.

Brock Purdy's pass was tipped at the line and the Arizona Cardinals snatched the ball from the air to secure a much-needed victory in San Francisco. Seconds earlier, Chad Ryland kicked a 35-yard field goal that put the Cardinals up 24-23.

Republic sports writers Bob McManaman and Theo Mackie discuss the Arizona Cardinals' win over the San Francisco 49ers in Santa Clara on Oct. 6, 2024.

The Arizona Cardinals fumbled their way into the second half but rallied back for a 24-23 win over the San Francisco 49ers on Sunday.

The game against the Arizona Cardinals marked the second time this season that San Francisco (2-3) blew a double-digit lead in the fourth quarter to a division rival, having done it in Week 3 against the Los Angeles Rams.