G protein-coupled receptors (GPCRs) are integral membrane proteins with seven membrane-spanning helices. Upon binding to a ligand – which can range from small molecules like cyclic AMP to ...

Adhesion G protein-coupled receptors (GPCRs) are a group of cell-surface sensors associated with many body functions and diseases. However, they are not yet sufficiently understood to be exploited for ...

Adhesion G protein-coupled receptors are a large class of membrane proteins that detect chemical and mechanical stimuli in the body. The GAIN domain ...

A recently published paper in Science China Life Sciences reports an interdisciplinary study utilizing single-cell sequencing ...

Lefkowitz started to trace cell receptors in 1968. Using radioactivity, he managed to unveil several receptors, including one for adrenalin, the β-adrenergic receptor. His team then extracted the ...

Scientists at the Faculty of Medicine have now developed an innovative numbering system for the GAIN domain, a protein domain ...

Proteins are life's engines, powering processes like muscle movement, vision, and chemical reactions. Their ...