G protein-coupled receptors (GPCRs) are integral membrane proteins with seven membrane-spanning helices. Upon binding to a ligand – which can range from small molecules like cyclic AMP to ...

Scientists from St. Jude Children's Research Hospital and the Medical College of Wisconsin have created a data science ...

Scientists have discovered how chemokines and G protein-coupled receptors selectively bind each other to control how cells move.

G protein-coupled receptors (GPCRs) are involved in many diseases, yet raising therapeutic antibodies against them is notoriously difficult because the transmembrane receptors contain only short ...

GenAI offers a realistic path forward in tackling previously undruggable targets, with the potential to reshape the entire therapeutic landscape and the whole drug discovery pipeline.

Tectonic Therapeutic, Inc.’s TECX share price has dipped by 7.37%, which has investors questioning if this is right time to ...

Drugs that act on GPCRs, or G protein-coupled receptors, include more than 400 medications approved by the U.S. Food and Drug Administration (FDA) for the treatment of many common conditions such ...

STRASBOURG, France, MONTREAL and BOSTON, April 1, 2025 /PRNewswire/ -- Domain Therapeutics ("Domain" or "the Company"), the GPCR experts harnessing deep receptor biology to develop breakthrough ...

Structure Therapeutics Inc.’s GPCR share price has surged by 29.14%, which has investors questioning if this is right time to sell.

The researchers analyzed chemokines and their associated G protein-coupled receptors (GPCRs), proteins that govern cell movement. They found that specific positions within structured and ...