To further understand the molecular mechanisms of peptide binding and receptor activation of GCGR, we solved the 3.0 Å-resolution crystal structure of the full-length GCGR bound to a glucagon ...

Recently, scientists at SIMM determined the crystal structure of GCGR in complex with a glucagon analogue and partial agonist NNC1702. This structure reveals, for the first time, the molecular ...

Class B G protein-coupled receptors (GPCRs) exert essential action in hormonal homeostasis and are important therapeutic targets for a variety of diseases including metabolic disorders such as ...

Glucagon Receptor Structure Offers New Opportunities for Type 2 Diabetes Drug Discovery. PUBLISHED ON January 04, 2018 10:23 AM - Complex structure of a class B GPCR bound to an analogue of its ...

Class B G protein-coupled receptors (GPCRs) exert essential action in hormonal homeostasis and are important therapeutic targets for a variety of diseases including metabolic disorders such as type 2 ...

Collaboration combines Novo Nordisk’s scientific leadership in obesity and cardiometabolic diseases with Septerna’s expertise in G protein-coupled receptor (GPCR) drug discovery Goal is to ...