Why retinoic acid is effective in this setting but not against primary tumors, has been speculated about for nearly 50 years. Scientists resolved the mystery, showing the drug 'hijacks' a normal ...

Neuroblastoma is a solid tumor that occurs in children. When high-risk, the disease has a poor prognosis. Decades ago, adding the drug retinoic acid to neuroblastoma treatment increased survival by 10 ...

Retinoic acid (RA) signalling is a fundamental biochemical pathway derived from vitamin A metabolism that orchestrates gene expression through its interaction with nuclear receptors. This signalling ...

(L to R) Co-first and co-corresponding author Min Pan, PhD, co-first author Yinwen Zhang, PhD, St. Jude Department of Computational Biology, co-corresponding author John Easton, PhD, St. Jude ...