This study's results contribute to the growing body of knowledge on the role of IFN signaling in bone diseases and pave the way for future research into the development of targeted therapies for OPLL.

The authors suggest that inhibition of IFN-γ signaling could provide a novel approach for the concomitant prevention of inflammation and bone loss in common osteoporotic conditions, including ...

The type I IFN signaling pathway was found to be activated during the progression of ossification, with IFN-related genes such as OAS2, OAS3, IRF7, MX1, MX2, and STAT1 exhibiting higher expression ...

The precise regulation of the RIG-I-like receptors (RLRs)-mediated type I interferon (IFN-I) activation is crucial in antiviral immunity and maintaining host immune homeostasis in the meantime. Here, ...