Nature14y
The novel JAK inhibitor AZD1480 blocks STAT3 and FGFR3 signaling, resulting in suppression of human myeloma cell growth and survival
AZD1480 blocks cell proliferation and induces apoptosis of myeloma cell lines. These biological responses to AZD1480 are associated with concomitant inhibition of phosphorylation of JAK2 ...
Nature11y
JAK inhibitors suppress t(8;21) fusion protein-induced leukemia
Apoptosis and relative cell numbers were measured ... for detection included rabbit antibodies against JAK1 (1:1000) or JAK2 (1:500) (Cell Signaling, Danvers, MA, USA), and mouse antibody against ...