心力衰竭及脂毒性心肌病中，junctophilin-2 (JP2)与junctin (JCN)表达下调导致Ca2+稳态失衡。本研究揭示JP2通过与JCN互作，阻断肌肉环指蛋白1 (MURF1)对JCN的泛素化降解，从而改善心肌功能。该轴为心脏 ...
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