Figure 1: Type 2 diabetes disease-state continuum and regulation of the leptin and insulin signalling pathways by PTP1B. Figure 2: Key aspects of the PTP1B X-ray crystal structure. A Gln262Ala ...

Here, we characterize two novel homozygous leptin variants that yielded antagonistic ... Details on protein structure modeling, activity, binding, internalization, and competition studies are ...

postnatal period of neuronal circuitry development may exert lasting effects on the structure and function of circuits that control energy balance. Leptin is a hormone that, in adults, regulates ...

The new study shows that leptin toggles a runner’s desire by cutting access to a reward chemical — dopamine — in one of the brain’s motivation centers, the ventral tegmental area.

Increasing leptin, a protein involved in regulating ... Researchers attribute the change in the cell's structure and function in rats – from fat storing to fat-burning – to a massive increase ...

postnatal period of neuronal circuitry development may exert lasting effects on the structure and function of circuits that control energy balance. Leptin is a hormone that, in adults, regulates ...