Figure 1: Type 2 diabetes disease-state continuum and regulation of the leptin and insulin signalling pathways by PTP1B. Figure 2: Key aspects of the PTP1B X-ray crystal structure. A Gln262Ala ...

Here, we characterize two novel homozygous leptin variants that yielded antagonistic ... Details on protein structure modeling, activity, binding, internalization, and competition studies are ...

The new study shows that leptin toggles a runner’s desire by cutting access to a reward chemical — dopamine — in one of the brain’s motivation centers, the ventral tegmental area.

Hormones are the body’s chemical messengers ... such as type 2 diabetes and heart disease. Leptin works by telling your hypothalamus — the portion of your brain that regulates appetite ...

The researchers found that the mutation in the Bdnf (brain-derived neurotrophic factor) gene undermines brain neurons’ ability to pass insulin and leptin chemical signals through the brain.

postnatal period of neuronal circuitry development may exert lasting effects on the structure and function of circuits that control energy balance. Leptin is a hormone that, in adults, regulates ...

postnatal period of neuronal circuitry development may exert lasting effects on the structure and function of circuits that control energy balance. Leptin is a hormone that, in adults, regulates ...

Increasing leptin, a protein involved in regulating ... Researchers attribute the change in the cell's structure and function in rats – from fat storing to fat-burning – to a massive increase ...

Withaferin A is a natural product with a steroidal structure. In 1962, Israeli chemists Asher Lavie ... Resistance to the hunger-regulating hormone leptin has long been known to contribute to obesity.