Following the discovery of leptin in 1994, the scientific and clinical communities have held great hope that manipulation of the leptin axis may lead to the successful treatment of obesity.

Most leptin supplements don’t actually contain the hormone leptin. Research is unclear whether these supplements can help you lose weight, but some studies suggest they can influence leptin ...

Structure and function Leptin is a 16 kDa adipose-derived protein comprising 167 amino acids. The hormone is coded for by the ob gene which is located on chromosome 7 in humans.

The identified leptin variants were submitted to the ClinVar ... transfection or stable viral transduction. Details on protein structure modeling, activity, binding, internalization, and ...

Having issues curbing your appetite? It might have something to do with your brain. Leptin is the satiating hormone. It is naturally secreted by your fat cells to suppress appetite; it's your ...

"The findings support the known role of leptin variations in late-life dementia risk by relating its deficiency with changes in white matter structure, which is an early event in the process of ...

D: It's a hormone produced by fat cells. Leptin plays a key role in regulating appetite and metabolism. When you eat, fat cells release leptin, which then binds to receptors in a part of your ...

Panel C shows the results after human embryonic kidney 293 (HEK293) cells were transiently transfected with empty vector or vector encoding nonmutant or D100Y leptin. After 48 hours, culture ...

John Krystal, MD, Editor of Biological Psychiatry, said of the findings, "Omrani and colleagues shed light on how, in non-obese animals, leptin puts the brakes on overeating." Leptin acts as a ...

I think I've read as much as I can read about Leptin & the role it plays in controlling weight. I'm hoping you can answer a few questions. I am a 58 year old post menopausal female who was a size ...

The sensation is tied to low levels of leptin — a brain hormone that tempers food consumption when you’ve had enough to eat, according to a study published today in the journal Cell Metabolism.