The need for regular blood transfusions, as well as underlying processes in MDS, can result in iron overload. If left untreated, excess iron can cause widespread damage to organs throughout the body.

β-Thalassemia is a genetic disorder characterized by reduced or absent synthesis of the beta chains of hemoglobin, leading to ineffective erythropoiesis and severe anemia. Patients with ...

BMP, bone morphogenetic protein; BMPR, bone morphogenetic protein receptor; HAMP, hepcidin; HFE, hereditary hemochromatosis protein; HJV, hemojuvelin; Holo-Tf, holo ...

Schematic hypothesis. Ischemic stroke causes iron accumulation, disrupting the redox balance, which in turn leads to two outcomes. One of the outcomes is the increased cell susceptibility to ...

USC researchers have uncovered a hidden driver behind the early and severe onset of Alzheimer's in people with Down syndrome: iron overload in the brain. Their study revealed that individuals with ...

Iron dysregulation contributes to MS progression through oxidative stress, ferroptosis, and immune activation, affecting neuronal and immune cell function. Both iron overload and deficiency exacerbate ...

Congenital anomalies and health outcomes among survivors of childhood cancer: A report from the childhood cancer survivor study. This is an ASCO Meeting Abstract from the 2023 ASCO Annual Meeting I.

New Cornell University research shows that individuals of East Asian ancestry have greater risk of elevated iron stores than people of Northern European ancestry, putting them at higher risk of ...

Sideroblastic anemia refers to a rare type of anemia in which a person’s iron levels remain high. If a person has sideroblastic anemia, their bone marrow does not use iron in the usual way when it ...

Dear Dr. Roach: I was prescribed iron for a low iron level due to “microcytic anemia.” I couldn’t tolerate oral iron because of constipation and hemorrhoids, so my doctor prescribed iron infusions.