An energy trap for tumor cells: Researchers find enzyme blockade halts liver cancer growth
Glycolysis is a central metabolic pathway by which cells obtain energy from sugar. Cancer cells in particular have long been ...
BioSpace9h
BioAge Stumbles Again, Drops Lead Obesity Molecule
It’s been a rocky few months for BioAge Labs, which shuttered a Phase II trial of its lead candidate azelaprag Tuesday after ...
ImmunoMet Therapeutics Presents Updated Clinical Data from Phase 1b Study of Lixumistat in Pancreatic Cancer at ASCO-GI Meeting
Press Release ImmunoMet Therapeutics, Inc., ("ImmunoMet", or the "Company"), a clinical stage biotechnology company committed to giving patients a novel approach to fight cancer, today provided a data ...
The EMBO Journal12d
Epigenetic modifications and metabolic gene mutations drive resistance evolution in response to stimulatory antibiotics
Resistance evolution in response to stimulatory antibiotics is driven by epigenetic modifications and mutations in metabolic ...
EurekAlert!9d
New approach to fighting cancer: Energy trap for tumor cells
Glycolysis is an important sugar degradation pathway that cancer cells in particular depend on. Scientists at the German Cancer Research Center (DKFZ) have now shown that liver cancer cells in mice ...
unige.ch4d
FZD inhibitors: finding the perfect fit
Frizzled (FZD) receptors are key players in a pathway called Wnt that promotes malignant cell growth, making them a promising ...
News Medical on MSN9d
SOX9 overexpression protects against lipid accumulation in MASH via AMPK activation
The transcription factor sex-determining region Y-related high-mobility group-box gene 9 (SOX9) plays a critical role in ...
EurekAlert!12d
SOX9 overexpression ameliorates metabolic dysfunction-associated steatohepatitis through activation of the AMPK pathway
Although SOX9 has been implicated in regulating lipid metabolism in vitro ... adenosine monophosphate-activated protein kinase (AMPK) inhibitor to test whether SOX9 acts via AMPK activation.