Organoids have revolutionized science and medicine, providing platforms for disease modeling, drug testing, and understanding ...

A comprehensive Thought Leaders Invited Review in Brain Medicine highlights the crucial role of CD2-associated protein (CD2AP) in Alzheimer’s disease (AD). CD2AP influences amyloid-beta processing, ...

Notably, microglia spatially associated with amyloid plaques exhibited increased expression of TREM2 and ApoE compared to such cells in non-immunized controls, regardless of whether the treatment was ...

Preclinical presentation highlights key, modality specific, pharmacological differentiations of VG-3927 - - First ...

have unveiled a critical mechanism that links cellular stress in the brain to the progression of Alzheimer's disease (AD). The study, published in the journal Neuron, highlights microglia ...

A research group led by Nagoya University Graduate School of Medicine in Japan has uncovered a potential mechanism linking ...

Microglia are brain-resident macrophages playing pivotal roles in CNS development and homeostasis. Yet, the cellular and molecular basis governing microglia maintenance ...

Genome-wide association studies have identified >20 loci with high Alzheimer’s Disease (AD) susceptibility, many of which overlap with genes highly expressed in microglia. These findings highlighted ...