Organoids have revolutionized science and medicine, providing platforms for disease modeling, drug testing, and understanding ...

These microglia then mount an inflammatory response ... the possibility of repurposing existing drugs that modify lipid metabolism. "We don't think this is an incidental phenomenon," said Chen.

Age-related neurodegenerative disorders — motor neuron diseases, demyelinating diseases, Alzheimer’s disease, and other ...

In a mouse model of TBI, microglia showed diminished itaconate levels and dysregulated energy metabolism, favouring production of mitochondrial reactive oxygen species and inflammatory mediators.

In females, however, Panx1 works through CD8+ T cells (a type of white blood cell) to release leptin, a hormone best known ...

Notably, microglia spatially associated with amyloid plaques exhibited increased expression of TREM2 and ApoE compared to such cells in non-immunized controls, regardless of whether the treatment was ...

A comprehensive Thought Leaders Invited Review in Brain Medicine highlights the crucial role of CD2-associated protein (CD2AP) in Alzheimer’s disease (AD). CD2AP influences amyloid-beta processing, ...

Microglia are brain-resident macrophages playing pivotal roles in CNS development and homeostasis. Yet, the cellular and molecular basis governing microglia maintenance ...

In particular, the researchers observed a significant increase in the number and turnover of microglia, the primary immune cells found in the central nervous system. The study also revealed ...

But not all microglia are created equal. Some are quite effective at removing plaques, while others struggle, the study found. Also, microglia in treated brains adopt distinct states depending on ...