The spindle assembly checkpoint arrests mitotic progression until each kinetochore secures a stable attachment to the spindle. Despite fluctuating noise, this checkpoint remains robust and remarkably ...

Steve Royle is a Senior Fellow for Cancer Research UK which funds his lab at Warwick University. Cells use a tiny machine called the mitotic spindle to share genetic material equally between cells ...

We have studied cytoskeletal architectures of isolated mitotic apparatus from sea urchin eggs using quick-freeze, deep-etch electron microscopy. This method revealed the existence of an extensive ...

Cell division is essential to the propagation of life. During cell division, mitotic spindles segregate duplicated chromosomes with high fidelity. Spindle structure depends on the proper polar ...

Scientists have gained new insight into the formation of the spindle, which is the molecular machine that divides up genetic material prior to cell division. Their work focuses on the motor protein, ...

Adam R. Lamson, Christopher Edelmaier, Matthew A. Glaser, and Meredith D. Betterton (2019). Biophysical Journal116, 1719. bioRxiv DOI: 10.1101/419135. DOI: 10.1016/j ...

Mitosis is the process by which the genetic information encoded on chromosomes is equally distributed to two daughter cells, a fundamental feature of all life on earth. Scientists now examine how ...

RanGAP1 was the first documented substrate for conjugation with the ubiquitin-like protein SUMO-1. However, the functional significance of this conjugation has not been fully clarified. We sought to ...

When a cell divides, it performs a feat of microscopic choreography—duplicating its DNA and depositing it into two new cells. The spindle is the machinery behind that process: It latches onto ...

Glioblastoma (GBM) is the most common and aggressive brain tumor in adults. Yet, there are currently no highly effective therapies to treat patients with GBM and ~90% patients die within 2 years of ...

Animals, from worms and sponges to jellyfish and whales, contain anywhere from a few thousand to tens of trillions of nearly genetically identical cells. Depending on the organism, these cells arrange ...