Fentanyl, a mu-opioid receptor agonist, is one of the most commonly used analgesics in hospitals, and may induce long-lasting behavioral and somatosensory impairment in rodents. However, whether the ...

A study of advanced cancer patients published in the journal Annals of Oncology and presented at this year's World Congress of Anaesthesiologists in Hong Kong suggests that opioid painkillers and ...

Due to the importance of dietary sodium and its paucity within many inland environments, terrestrial animals have evolved an instinctive sodium appetite that is commensurate with sodium deficiency.

The opioid system controls pain, reward and addictive behaviors. Opioids exert their pharmacological actions through three opioid receptors, mu, delta and kappa whose genes have been cloned (Oprm, ...

Nicotine replacement therapies (NRTs), including transdermal nicotine, nicotine gum, and nicotine nasal spray, are effective treatments for tobacco dependence. 1 However, there is substantial ...

Anna E. Mechling, Tanzil Arefin, Hsu-Lei Lee, Thomas Bienert, Marco Reisert, Sami Ben Hamida, Emmanuel Darcq, Aliza Ehrlich, Claire Gaveriaux-Ruff, Maxime J. Parent ...

Having a pill that alleviates chronic pain without adverse side effects or the risk of addiction remains an unmet pharmaceutical need for millions of people currently using traditional opioid drugs.

A new drug could potentially kill pain as effectively as morphine at a dose 100 times smaller–and without the risk of addiction. In a new study, the drug, called AT-121, relieved pain in monkeys ...

BIRMINGHAM, Ala. – Researchers at the University of Alabama at Birmingham (UAB) have uncovered the genetic identity of a cellular receptor for the immune system's first-response antibody, a discovery ...

Opioid painkillers and their receptor in cells -- the mu opiate receptor -- could be involved in cancer progression, and could thus be a target for treatments, a study of advanced cancer patients ...

Endorphins became a household word in the late 1970s when Candace Pert and colleagues (Snyder & Simantov, 1977) at Johns Hopkins University School of Medicine made front-page news by identifying ...