U-II was found to increase afterload and reduce myocardial contractility. Its effect at high concentrations is best rationalized by myocardial ischemia. Using the calculations of Sunagawa et al.

and may augment myocardial contractility in subjects with heart failure. Further studies are required to confirm whether these promising initial findings yield demonstrable and clinically ...

After a myocardial infarction, scarring and fibrosis of the LV wall leads to thinning, thereby increasing wall stress. Contractility: Contractility is the force of systolic contraction.

It operates as a positive inotropic agent, enhancing myocardial contractility by inhibiting Na+/K+-ATPase. Simultaneously, it promotes myocardial relaxation by activating the SERCA2a calcium pump ...

Lignocaine has no effect on supraventricular tachycardia (SVT). Like most antiarrhythmic drugs, lignocaine depresses myocardial contractility, and toxic levels can produce paraesthesia, drowsiness, ...

decreasing heart rate and myocardial contractility, and a resetting of the baroreceptors. [6] β-blockers differ from one another, however, with regard to many pharmacologic properties ...