Whereas circadian period length in Drosophila melanogaster is directly connected to Per protein phosphorylation and stability 4, the molecular correlate for period length in mammals is not known.
Researchers find that a key circadian clock controlling kinase, CK1D -- controlling the stability of PER2 -- has two forms, one that stabilizes PER2 and one that destabilizes it. A long-studied factor ...
Due to a loss of functionality in hematopoietic stem cells, immune defects occur during aging. Now, researchers have identified gene Per2, whose deletion leads to a stabilization of the number of ...
No significant financial relationships to disclose. This is an ASCO Meeting Abstract from the 2008 ASCO Annual Meeting. This abstract does not include a full text component.
Mice lacking the Period 2 (Per2) gene, a gene associated with circadian rhythm, are considered a potential animal model for studying vulnerability to drug abuse. However, their response towards ...
Kyoto, Japan -- A long-studied factor controlling human sleep cycles actually has two forms, one that keeps a key protein stable and another that promotes its degradation. From the heart and lungs ...
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