Prostaglandins in development and aging: Immunohistochemical studies on the localization of PGD 2 synthetase in rat brain have shown that the major site changed from neuron to oligodendroglia with age ...

NSAIDs are the most widely studied treatment because they inhibit prostaglandin synthetase release and decrease the production of endometrial prostaglandins.

Microsomal PGE synthase 1 (mPGES-1) is the terminal enzyme in the induced state of prostaglandin E2 (PGE2) synthesis and constitutes a therapeutic target for rheumatoid arthritis (RA) treatment.

Aspirin does this by blocking an enzyme known as prostaglandin synthetase. The body needs the enzyme to make precursors for most of the half-dozen known prostaglandins and a few other key substances.

Recent breakthroughs in understanding the prostaglandin D2 (PGD2) receptor 1 (DP1) are paving the way for innovative anti-inflammatory and immunomodulatory therapies.