Acute myeloid leukemia (AML) is an aggressive cancer affecting the blood and bone marrow that progresses rapidly, making ...

Published in Genome Biology, the research into ‘domain atrophy’ offers new insights into the evolution, molecular mechanism, stability and function of protein domains. Proteins are everywhere, ...

They attached each protein domain variant to an enzyme that is essential for yeast and quantified cell growth rate as a proxy for domain stability. By comparing protein abundance before and after the ...

Proteins have been quietly taking over our lives since the COVID-19 pandemic began. We've been living at the whim of the virus's so-called "spike" protein, which has mutated dozens of times to ...

One protein, Las17, was identified as a key member of this network, and additional experimental data confirmed that Las17 interacts with many SH3 domain proteins through multiple proline-rich domains.

Toll-like receptors, or TLRs, are the immune system’s early warning sensors. They detect microbial invaders and damage ...

WIKIMEDIA, CHAOS Using the CRISPR/Cas9 genome-editing system to mutate the gene regions encoding particular protein domains could result in a new and more efficient method to screen for druggable ...

Model predicts binding partners of domains that mediate crucial protein-protein interactions Please click here if you are not redirected within a few seconds. Advertisement ...

Adhesion G protein-coupled receptors are a large class of membrane proteins that detect chemical and mechanical stimuli in the body. The GAIN domain plays a central role in the activation of ...

Researchers at EMBL-EBI have shown that protein domains, previously thought to be indivisible, complete units that make up proteins, can exist and function despite having lost large parts of their ...