although they function in similar ways. Chaperone proteins are abundant in cells. These chaperones use energy from ATP to bind and release polypeptides as they go through the folding process.

Proper protein folding is essential for maintaining their biological functions. However, proteins can sometimes misfold, leading to the formation of aggregates or fibrils that are associated with ...

"Now, this work opens the possibility that even with the same amino acid sequence, you can design new protein structures and functions simply by changing the folding conditions." More information ...

This kind of tight folding and packing minimizes the ... effect that eventually kills the cell or impairs its function. A prime example of proteins that catalyze their own conformational change ...

All biological function is dependent on how different ... in biology in recent years due to its ability to predict protein ...

One form of modification is protein splicing. The protein initially contains a so-called ‘intein’, which removes itself from ...

Although the rational protein design approach offers an increased possibility of beneficial alterations, it is not easy to accurately predict the sequence-structure-function relationship, particularly ...

A team of Chinese researchers led by Prof. WANG Likun from the Institute of Biophysics of the Chinese Academy of Sciences has provided new insights into metabolic disease mechanisms and potential ...

Key structural and mechanistic insights into BSEP transporter mutations that lead to improper protein folding and functionFindings have ...