All biological function is dependent on how different ... in biology in recent years due to its ability to predict protein ...

although they function in similar ways. Chaperone proteins are abundant in cells. These chaperones use energy from ATP to bind and release polypeptides as they go through the folding process.

"Now, this work opens the possibility that even with the same amino acid sequence, you can design new protein structures and functions simply by changing the folding conditions." More information ...

"Predicting the three-dimensional structures and motions of proteins is integral to understanding their functions and designing ... that otherwise guides the folding, called local frustration ...

This kind of tight folding and packing minimizes the ... effect that eventually kills the cell or impairs its function. A prime example of proteins that catalyze their own conformational change ...

Proper protein folding is essential for maintaining their biological functions. However, proteins can sometimes misfold, leading to the formation of aggregates or fibrils that are associated with ...

One form of modification is protein splicing. The protein initially contains a so-called ‘intein’, which removes itself from ...

Proteins form the structural and functional backbone of the cell, and any perturbation in their synthesis can disrupt normal ...

A team of Chinese researchers led by Prof. WANG Likun from the Institute of Biophysics of the Chinese Academy of Sciences has provided new insights into metabolic disease mechanisms and potential ...

HHMI researchers bring the arcane world of protein folding to the online gaming arena with the launch ... of information—revealing intricacies about the protein’s biological function and suggesting ...

Although the rational protein design approach offers an increased possibility of beneficial alterations, it is not easy to accurately predict the sequence-structure-function relationship, particularly ...