Proteins are large, complex molecules that carry out the tasks of life. They direct our bodies' activities, organize our thoughts, and defend us against infection, keeping us healthy. But in their ...

Structural mass spectrometry has emerged as a powerful approach to elucidate the three‐dimensional conformations of proteins and their complexes under near‐physiological conditions. In particular, ...

Just like workers need the right environment to efficiently perform their tasks, proteins require placement within specific cellular compartments to function properly. Therefore, understanding the ...

Mass Spectrometry is a scientific technique used to measure proteins by determining the mass to charge ratio of a molecule in a sample. Measurements generated with Mass Spectrometry can measure the ...

Historically, these factors have made the identification of proteins incredibly challenging. The advent of mass spectrometry (MS) and MS-based proteomics helped to change that. 2 MS is an analytical ...

Technological advances in mass spectrometry are aiding researchers to image and characterize protein and other cellular components with increasing resolution. Using native ambient mass spectrometry ...

A screening technique commonly used in drug discovery can yield important details about the actions of molecular ‘glues’ in protein interactions. Molecular glues are emerging as powerful therapeutic ...

This Clinical Chemistry and Laboratory Medicine review examines a central challenge in precision medicine: whether medical ...

As our bodies run multiple parallel processes, they shuttle a flurry of messages around inside—often as protein-metabolite interactions (PMIs), where small molecules bind to a protein and initiate or ...

Antibody arrays: removal of high abundance proteins is not required, but antibody availability limits protein detection. Mass spectrometry: “hypothesis-free” protein detection is affected by high ...

Daily administration of MGCD265 to patients with solid tumors in a dose-escalation phase I study (study 265-101). Background: To evaluate SELDI as a potential technique for predicting response to ...