Endosomal trafficking and protein sorting constitute fundamental processes that govern the intracellular localisation and recycling of membrane proteins in eukaryotic cells. Endosomes act as central ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 110, No. 11 (March 12, 2013), pp. 4285-4290 (6 pages) Thermodynamic stabilities are pivotal for understanding ...

Classic studies of temperature-sensitive secretory (sec) mutants have demonstrated that secreted and plasma membrane proteins follow a common SEC pathway via the endoplasmic reticulum (ER), Golgi ...

A study recently posted to the bioRxiv* preprint server identified Neurolipin-1 or NRP1, a host factor for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection, as a cargo retrograde ...

Researchers at the University of Pennsylvania School of Medicine have discovered how a protein called Pmel17 is sorted by pigment cells in the skin and eye to make a fiber matrix that eventually ...

The tension in the membrane of cells plays an important role in a number of biological processes. A localized drop in tension makes it easier for the surface to be bending inward and form ...

Like a sorting machine in an assembly line, a molecule known as VPS35 detects and removes defective proteins from neurons. And similar to other quality control processes, the VPS35 system goes a long ...

Researchers have deciphered a biochemical mechanism that ensures that newly formed proteins are processed correctly when they leave the cell's own protein factories. This solves a decade-old puzzle in ...

F.-U. Hartl, W. Neupert, "Protein sorting to mitochondria: evolutionary conservations of folding and assembly," Science, 247:930-38, 1990. Franz-Ulrich Hartl (University of Munich, Germany): "In this ...

The secretory pathway in eukaryotic cells is crucial for maintaining cellular function and physiological activities, as it ensures the accurate transport of proteins to specific subcellular locations ...

Based on genetic blueprints, individual amino acids are assembled into long amino acid chains, the proteins, in the protein factories of our cells, the ribosomes. Each newly formed protein starts with ...