The 49ers just blew another 10-point fourth quarter lead and lost 24-23 to the Arizona Cardinals. Now the 49ers are 2-3. Here are their grades for this pathetic performance.

SANTA CLARA—The West Coast heatwave wreaked havoc on the 49ers’ practice schedule this past week, leading coach Kyle Shanahan to joke that he, like his players, will take intravenous fluids to rehydrate. “I still do it, if I had too much fun the night before,” Shanahan said.

The 49ers are a 7.5-point favorite over the Cardinals in NFL Week 5 odds for the game, courtesy of BetMGM Sportsbook. San Francisco is -375 on the moneyline, while Arizona is +300. The over/under (point total) is set at 49.5 points.

With the San Francisco 49ers (2-3) and the Seattle Seahawks (3-2) squaring off on Oct. 10 at Lumen Field, Brock Purdy and Geno Smith will go toe to toe at the quarterback position. We break down the two signal callers below,

QB Brock Purdy speaks to reporters after San Francisco's 24-23 loss to the Arizona Cardinals on Sunday at Levi's Stadium and discusses the need to quickly adjust on a short week before a Week 6 matchup with the Seattle Seahawks.