SportsLine's model simulated Arizona Cardinals vs. San Francisco 49ers 10,000 times and made its Week 5 NFL picks, ...

SportsLine's advanced computer model locked in the top NFL office pool picks for Week 5 of the 2024 NFL schedule ...

Anyone trekking from Sacramento to the Bay Area on Sunday to watch the San Francisco 49ers would be mistaken for thinking ...

The San Francisco 49ers appear to be back. The team entered Week 4 with a 1-2 record and desperately needed a win over the ...

The San Francisco 49ers have added another player to the injury report. Star tight end George Kittle will miss Sunday's game ...

The San Francisco 49ers ran the New York Jets into submission Monday, winning their Week 1 matchup 32-19. Third-year running back Jordan Mason, starting in place of the injured Christian McCaffrey ...

Brock Purdy threw a touchdown pass, Fred Warner returned an interception for a score and the San Francisco 49ers snapped a two-game skid by beating the New England Patriots 30-13 on Sunday.

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The 2-2 49ers also elevated receiver Trent Taylor and defensive lineman T.Y. McGill Jr. from the practice squad for Sunday’s game. Cardinals tight end Trey McBride was cleared from concussion protocol ...

Brock Purdy and the San Francisco 49ers took on Aaron Rodgers and the New York Jets on Monday Night Football in their season opener at Levi’s Stadium as they seek to return to the Super Bowl.