The toad’s own 5-MeO-DMT was first reported in the mid-1960s, ... some participants fell into what seemed like a calm sleep, while others screamed or rolled around on their floor mattresses, ...

The Sonoran Desert toad secretes an enzyme that converts bufotenine, a compound also made by other toads, into 5-MeO-DMT, ... fasting and in some cases sleep deprivation, ...