Centrosome duplication is tightly regulated to ensure that centrioles duplicate only once per cell cycle and that only one new centriole is produced per pre-existing centriole Phosphorylation events ...

Science paper also describes Orc1’s mechanism of action. Researchers at Cold Spring Harbor Laboratory have discovered the protein that controls the copying of the centrosome in human cells and ...

This is a preview. Log in through your library . Abstract Newt eosinophils are motile granulated leukocytes that uniquely display a highly visible centrosomal area. Electron microscope and tubulin ...

This news release is available in German. The duplication of cellular contents and their distribution to two daughter cells during cell division are amongst the most fundamental features of all life ...

The centrosome and spindle pole body community gathered for its triennial meeting from 12–16 September, 2008 at EMBL in Heidelberg (Germany). Microtubules and their constellation of associated ...

A dividing cell duplicates its chromosomes and its centrosome, an organelle that helps divide the two sets of chromosomes equally to daughter cells, just once. Extra centrosome copies can lead to ...

The nuclear-centrosome complex was isolated from interphase Chinese hamster ovary (CHO) cells, and, with exogenous brain tubulin as a source of subunits, the centrosome, while attached to the nucleus, ...

All life on earth depends upon the process of mitosis or cell division in which the chromosomal content of a cell is equally divided between two new cells. For mitosis to occur, the chromosomes in ...

The goal of my research is to understand the biogenesis of centrioles/centrosomes and primary cilia, and how defects in these processes affect mammalian cell physiology and evoke stress responses.

The story of the cell cycle is often told only through the perspective of the chromosomes as they replicate and then divide. This resource beautifully illustrates the role of the cytoskeleton in that ...

Most knowledge on centrioles has been built by studying dividing animal cells in a narrow group of species, like flies or humans. “Recent technological advances in several fronts allow us to study ...

Cytotoxic drugs or cytostatics are drugs used to destroy cancer cells. Cytotoxic drugs inhibit cell division and in this way cause cancer cells to die. But current treatments inevitably have negative ...