Denver is a 2.5-point favorite in the latest Broncos vs. Colts odds from SportsLine consensus, while the over/under for total points scored is 43.5. Before making any Colts vs. Broncos picks, make sure you check out the picks from the SportsLine Projection Model.

Daniel Jones was near-perfect in his debut with the Colts completing 22 of 29 passes (75.9%) for 272 yards including one touchdown and two more on the ground in a 33-8 smackdown of the Miami Dolphins. The win snapped an 11-game losing streak on Opening Day for Indy.

The Denver Broncos are fresh off of a Week 1 victory over the Tennessee Titans and will now get another opportunity for a win against the AFC South in Week 2. Amid some struggles from quarterback Bo Nix and the offensive side of the football,

Bo Nix threw two interceptions and lost a fumble and the team had four turnovers. But they held Tennessee out of the end zone and still won by eight points despite a sloppy performance. While many will laugh at those who labeled the Broncos a dark horse Super Bowl contender, others are going to look at the glass as half full.

The Denver Broncos and Indianapolis Colts will face each other in a meeting between two 1-0 teams in Week 2. If you want to find out the latest odds for the gam

The 2024 NFL Defensive Player of the Year started the 2025 season with a stat line that showed one pass breakup. But that was all that Denver cornerback Patrick Surtain II could have recorded in the Broncos’ 20-12 victory over the Tennessee Titans.